ACE-Inhibitors in High Vascular Risk: From Experimental Medicine to
نویسندگان
چکیده
Copyright: © 2013 Angeli F. et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The Renin-Angiotensin System (RAS) is a complex regulatory system with many identifiable actions. It may primarily be viewed as a powerful regulatory system for the conservation of salt, blood volume and Blood Pressure (BP) [1]. However, an increased activity of the RAS, especially in combination with other cardiovascular (CV) risk factors, may lead to a cascade of deleterious effects.
منابع مشابه
Quinapril Attenuates the Effect of Long-Term L-NAME Administration on the Vascular Reactivity of Diabetic Rats
Angiotensin-converting enzyme (ACE) inhibitors including quinapril could exert a protective effect on cardiovascular system through endothelial system in normoglycemic and diabetic rats. The present experimental work was designed to study the vascular reactivity of aortic ring segments isolated from streptozotocin (STZ)-diabetic rats treated for 4 weeks with nitro-L-arginine-methyl ester (L-NAM...
متن کاملInhibitory Effects of Germinal Angiotensin Converting Enzyme by Medicinal Plants Used in Iranian Traditional Medicine as Antihypertensive
Background & Aim: Medicinal plants are used in traditional medicine for the treatment of different diseases such as hypertension. Since inhibition of angiotensin converting enzyme (ACE) is one of the involved mechanisms in control of hypertension, in this study the inhibitory effect of 20 medicinal plants on ACE was investigated. Methods: The medicinal plants were collected, powdered, extracted...
متن کاملCardiovascular Pharmacology: Open Access ACE-Inhibitors in High Vascular Risk: From Experimental Medicine to Clinical Trials
Copyright: © 2013 Angeli F. et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The Renin-Angiotensin System (RAS) is a complex regulatory system with many identifiable actions. It may primarily be viewed a...
متن کاملDrug Therapy for Small Abdominal Aortic Aneurysm
Dear Editor,Abdominal aortic aneurysm is often asymptomatic, less recognized, and causes considerable mortality and morbidity, if missed. The incidence varies from country to country and the occurrence is influenced by modifiable (smoking, coronary heart disease, hypertension, dyslipidemia, and prolonged steroid therapy) and non-modifiable risk factors (increasing age, male gender, and positive...
متن کاملبررسی ارتباط بین فشار خون سیستولی و فعالیت آنزیم مبدل آنژیوتانسین (ACE) در موش صحرایی دیابتی شده توسط استرپتوزوتوسین
Background: Due to homeostatic and regulatory potentials of nitric oxide (NO) in vascular physiology, regulatory systems that determine NO bio-synthesis and bioavailability have been the subject of extensive research in molecular medicine. In the field of vascular system pathophysiology, endothelial nitric oxide synthase (eNOS) which is the major producer and regulator of NO in vascular tissues...
متن کامل